Ipamorelin is a penta-peptide hormone that consists of amino acid chain Aib-His-D-2-Nal-D-Phe-Lys-NH2 . The hormone is classified under the GHRPs and is vital in causing the secretion of growth hormone. Just like GHRP-2 and GHRP-6. Ipamorelin was first studies in the early 90s and has since caught the eyes of researchers from different areas of science. The hormone functions by accentuating the somatoropes. The mechanism of action of ipamorelin is synergistic; it works in synergy other peptides such as Sermorelin and modified GRF 1-29. The synergy comes by the suppression of Somatostatin and the increase of the number of somatoropes by GHRH while ipamorelin increases the production of GH released per somatorope.
Ipamorelin has similar properties with CJC1295 DAC in that they both release at the same strength and amounts. GHRP-2 and GHRP-6 are known to induce the increment of prolactin and cortisol in the plasma, ipamorelin has the same properties as hexarelin because they are both the most stable form of Ghrelin and have long half life and has a secondary effect of exciting the neurons. The hormone has a molecular mass of 711.86 Daltons, and does not cause any significant effect on the levels of IGF-1. Ipamorelin increases the levels of acetylcholine in the system, which means the neural communication is at its best, it binds the cell receptors and brings about response. According to research, the hormone increases gastric motility and its mechanism of action is through the activation of a specific G-protein secretagogues. Moreover studies shows that the hormone targets the growth hormone receptors in the pituitary gland and does not affect the FSH, LH, TSH or PRL levels in the blood serum.
The GRLN receptor has been identified as the receptor for peptide or secretagogues receptor; it activates minute compounds on the pituitary gland to release growth hormone. Ipamorelin acts on the same receptor and triggers the pituitary to release the hormone; the hormone is responsible for cell division, cell proliferation, and differentiation. The effects are independen stimulation by which neuropeptide. Endogenous Ghrelin and ipamorelin have a high affinity for the GRLN receptors and can penetrate cells quicker reaching the neighboring structures with ease.