GHRPs are a small family of peptides located at the hypothalamus and pituitary and they accentuate the release of growth hormones through the activation of a specific G- protein coupled receptor. The peptides were discovered two decades ago as synthetic metenkephalin derived oligopeptides or synthetic tissue derived amino acids. There is no structural homology between these peptides and growth hormone releasing hormone. The peptide acts on the pituitary and hypothalamus gland to release the growth hormone and has a slight simulator effect on prolactin, cortisol, and ACTH levels.
PT 141 Peptide has a sequence, which includes the following amino acids H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2. However, research shows that its activity is increased if they are administered together. GHRP-2 peptide receptors interact with a hormone referred to as Ghrelin.