Lipotropin is secreted when POMC or pro-opiomelanocortin undergoes cleaving at the anterior lobe of the pituitary gland. Beta lipotropin consists of ninety amino acids and it forms the carbonyl carbon in the pro-opiomelanocortin fragment. The peptide is vital because it stimulates the secrete of melanin from melanocytes, possible fragment of the beta lipotropin include beta endorphin, gamma endorphin, alpha MSH, metenkephalin and alpha endorphin. Beta lipotropin mobilizes lipids, this is mainly through lipolysis, and steroidogenesis, the synthetic version of the hormone is AOD9604.
AOD9604 is a polypeptide fragment from the amino acid number 177 to 191 (177-191) of the C terminal thereafter tyrosine is added to the N-terminal. AOD9604 promotes lipolysis and inhibits lipogenesis, which is the transfer of excess energy or glucose to the peripheral and abdominal organs. The peptide has a molecular formula C78H123N23O23S2 and a molecular mass of 1.82-kilo Daltons. Some of the synonyms include 221231-10-3, AOD9604 and HGH Fragment 177-191.
The region discovered was 177-191 of the amino acid sequence. The polypeptide has no effect on insulin resistance, growth and development, the mechanism of action is through biomimicry of the growth hormone functions.
Depends on the information sequence. AOD9604 is the region of high accessibility to proteases and is rich in amino acid proline, this affects the conformational change in the cytoplasmic domain of band 3 and pivots two domains. Research shows that ACTH 1-24 has an adverse effect on the level of cyclic AMP, the level of cAMP is independent of the production of angiotensin II and aldosterone.